New Method Delivers One-Two Punch to Cancer
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This illustration depicts the nanolipogel administering its immunotherapy cargo. Image: Nicolle Rager Fuller, NSF
Cancers are notorious for secreting chemicals that confuse the immune system and thwart biological defenses. To counter that effect, some cancer treatments try to neutralize the cancer's chemical arsenal and boost a patient's immune response — though attempts to do both at the same time are rarely successful.
Now, researchers have developed a novel system to simultaneously deliver a sustained dose of both an immune-system booster and a chemical to counter the cancer's secretions, resulting in a powerful therapy that, in mice, delayed tumor growth, sent tumors into remission and dramatically increased survival rates.
The researchers, all from Yale Univ., report their findings in Nature Materials.
The new immunotherapy incorporates well-studied drugs, but delivers them using nanolipogels (NLGs), a new drug transport technology the researchers designed. The NLGs are nanoscale, hollow, biodegradable spheres, each one capable of accommodating large quantities of chemically diverse molecules.
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